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    Intra-Helical Salt Bridge Contribution to Membrane Protein Insertion.

    Reference

    Duart G, Lamb J, Ortiz-Mateu J, Elofsson A, Mingarro I. Intra-Helical Salt Bridge Contribution to Membrane Protein Insertion. J Mol Biol. 2022 Jan 29;434(5):167467. doi: 10.1016/j.jmb.2022.167467. Epub ahead of print. PMID: 35093395.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles.

    Reference

    Bañó-Polo M, Martínez-Gil L, Sánchez Del Pino MM, Massoli A, Mingarro I, Léon R, Garcia-Murria MJ. Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles. J Oral Microbiol. 2022 Jan 24;14(1):2030094. doi: 10.1080/20002297.2022.2030094. PMID: 35087641; PMCID: PMC8788378.

    [DOI] [PMCID] [Abstract] [Full text] [Full text PDF] [ePub]

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    Folding and Insertion of Transmembrane Helices at the ER.

    Reference

    Whitley P, Grau B, Gumbart JC, Martínez-Gil L, Mingarro I. Folding and Insertion of Transmembrane Helices at the ER. Int J Mol Sci. 2021 Nov 26;22(23):12778. doi: 10.3390/ijms222312778. PMID: 34884581.

    [DOI] [Abstract] [Abstract] [Full text] [Full text PDF]

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    Controllable membrane remodeling by a modified fragment of the apoptotic protein Bax.

    Reference

    Schaefer KG, Grau B, Moore N, Mingarro I, King GM, Barrera FN. Controllable membrane remodeling by a modified fragment of the apoptotic protein Bax. Faraday Discuss. 2021 Sep 22. doi: 10.1039/d0fd00070a. Epub ahead of print. PMID: 34549736.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Methodological approaches for the analysis of transmembrane domain interactions: A systematic review.

    Reference

    Gerard Duart, Brayan Grau, Ismael Mingarro, Luis Martinez-Gil. Methodological approaches for the analysis of transmembrane domain interactions: A systematic review. Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1863, Issue 12, 2021, 183712, ISSN 0005-2736.

    [DOI] [Full text] [Full text PDF]

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    Conformational clamping by a membrane ligand activates the EphA2 receptor.

    Reference

    Westerfield JM, Sahoo AR, Alves DS, Grau B, Cameron A, Maxwell M, Schuster JA, C T Souza P, Mingarro I, Buck M, Barrera FN. Conformational clamping by a membrane ligand activates the EphA2 receptor. J Mol Biol. 2021 Jul 3:167144. doi: 10.1016/j.jmb.2021.167144. Epub ahead of print. PMID: 34229012.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    The importance of transmembrane domain interactions in the viral control of apoptosis.

    Reference

    Duart G, Mingarro I, Martinez-Gil L. The importance of transmembrane domain interactions in the viral control of apoptosis. Mol Cell Oncol. 2021 May 3;8(3):1911290. doi: 10.1080/23723556.2021.1911290. PMID: 34027047; PMCID: PMC8128167.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    The SARS-CoV-2 envelope (E) protein has evolved towards membrane topology robustness.

    Reference

    Duart G, García-Murria MJ, Mingarro I. The SARS-CoV-2 envelope (E) protein has evolved towards membrane topology robustness. Biochim Biophys Acta Biomembr. 2021 Mar 23:183608. doi: 10.1016/j.bbamem.2021.183608. Epub ahead of print. PMID: 33771486.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Role of pulmonary surfactant protein Sp-C dimerization on membrane fragmentation: An emergent mechanism involved in lung defense and homeostasis.

    Reference

    Barriga A, Morán-Lalangui M, Castillo-Sánchez JC, Mingarro I, Pérez-Gil J, García-Álvarez B. Role of pulmonary surfactant protein Sp-C dimerization on membrane fragmentation: An emergent mechanism involved in lung defense and homeostasis. Biochim Biophys Acta Biomembr. 2021 Feb 4;1863(6):183572. doi: 10.1016/j.bbamem.2021.183572. Epub ahead of print. PMID: 33548215.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Towards peptide-based tunable multistate memristive materials.

    Reference

    Cardona-Serra S , Rosaleny LE , Giménez-Santamarina S , Martínez-Gil L , Gaita-Ariño A. Towards peptide-based tunable multistate memristive materials. Phys Chem Chem Phys. 2021 Jan 28;23(3):1802-1810. doi: 10.1039/d0cp05236a. PMID: 33434247.

    [DOI] [Abstract]

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    Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis.

    SEBBM article of the month

    Reference

    García-Murria MJ, Duart G, Grau B, Diaz-Beneitez E, Rodríguez D, Mingarro I, Martínez-Gil L. Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis. Nat Commun. 2020 Nov 27;11(1):6056. doi: 10.1038/s41467-020-19881-9. PMID: 33247105; PMCID: PMC7695858.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis.

    Reference

    Lucendo E, Sancho M, Lolicato F, Javanainen M, Kulig W, Leiva D, Duart G, Andreu-Fernández V, Mingarro I, Orzáez M. Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis. Proc Natl Acad Sci U S A. 2020 Oct 22:202008885.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    SARS-CoV-2 envelope protein topology in eukaryotic membranes.

    Reference

    Gerard Duart, Mª Jesús García-Murria, Brayan Grau, José M. Acosta-Cáceres, Luis Martínez-Gil and Ismael Mingarro SARS-CoV-2 envelope protein topology in eukaryotic membranes. Open Biology, 10. The Royal Society. [9-9-2020]

    [DOI] [Full text]

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    Coronavirus proteases: a priority target in the search for antivirals.

    Reference

    Ismael Mingarro, Iñaki Tuñón Coronavirus proteases: a priority target in the search for antivirals. Mètode. Universitat de Valencia. [25-6-2020]

    [Full text] [Full text PDF]

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    Coronavirus: knowing our enemy. COVID-19 has become an unprecedented pandemic.

    Reference

    Ismael Mingarro Coronavirus: knowing our enemy. COVID-19 has become an unprecedented pandemic. Mètode. Universitat de Valencia. [31-3-2020]

    [Full text] [Full text PDF]

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    A conversation with Peter Palese.

    Reference

    Luis Martinez-Gil A conversation with Peter Palese. Biofísica - SBE Magazine #16 [January - April 2020]

    [Full text] [Full text PDF]

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    Insertion of Bacteriorhodopsin Helix C Variants into Biological Membranes.

    Reference

    Manuel Bañó-Polo, Luis Martínez-Gil, Francisco N. Barrera, Ismael Mingarro Insertion of Bacteriorhodopsin Helix C Variants into Biological Membranes. ACS Omega 2020, 5, 556−560.

    [Abstract] [Full text PDF]

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    A Bimolecular Multicellular Complementation System for the Detection of Syncytium Formation: A New Methodology for the Identification of Nipah Virus Entry Inhibitors.

    Reference

    García-Murria MJ, Expósito-Domínguez N, Duart G, Mingarro I, Martinez-Gil L. A Bimolecular Multicellular Complementation System for the Detection of Syncytium Formation: A New Methodology for the Identification of Nipah Virus Entry Inhibitors. Viruses. 2019 Mar 7;11(3). pii: E229.

    [Abstract] [Abstract] [DOI] [Full text] [Full text PDF]

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    How do membrane proteins fold?

    Reference

    Ismael Mingarro. How do membrane proteins fold? Biofísica - SBE Magazine #13 [January - April 2019]

    [Full text] [Full text PDF]

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    Transmembrane but not soluble helices fold inside the ribosome tunnel.

    Selected by SBE (Spanish Biophysical Society) as “Paper of the Month”

    Reference

    Manuel Bañó-Polo, Carlos Baeza-Delgado, Silvia Tamborero, Anthony Hazel, Brayan Grau, IngMarie Nilsson, Paul Whitley, James C. Gumbart, Gunnar von Heijne & Ismael Mingarro. Transmembrane but not soluble helices fold inside the ribosome tunnel. Nature Communicationsvolume 9, Article number: 5246 (2018).

    [Abstract] [DOI] [Full text] [Full text PDF]

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    The Lsm1-7/Pat1 complex binds to stress-activated mRNAs and modulates the response to hyperosmotic shock.

    Reference

    Elena Garre, Vicent Pelechano, Manuel Sánchez del Pino, Paula Alepuz, Per Sunnerhagen. The Lsm1-7/Pat1 complex binds to stress-activated mRNAs and modulates the response to hyperosmotic shock. PLoS Genet. 2018 Jul 30;14(7):e1007563. doi: 10.1371/journal.pgen.1007563. eCollection 2018 Jul.

    [Abstract] [DOI] [Full text] [Full text PDF]

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    In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets.

    Reference

    Segura V, Valero ML, Cantero L, Muñoz J, Zarzuela E, García F, Aloria K, Beaskoetxea J, Arizmendi JM, Navajas R, Paradela A, Díez P, Dégano RM, Fuentes M, Orfao A, Montero AG, Garin-Muga A, Corrales FJ, Pino MMSD. In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets. Proteomes. 2018 Feb 5;6(1). pii: E8. doi: 10.3390/proteomes6010008.

    [Abstract] [Abstract] [Full text] [Full text PDF]

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    Dissecting the individual contribution of conserved cysteines to the redox regulation of RubisCO.

    Reference

    García-Murria MJ, Sudhani HPK, Marín-Navarro J, Sánchez Del Pino MM, Moreno J. Dissecting the individual contribution of conserved cysteines to the redox regulation of RubisCO. Photosynth Res. 2018 Mar 10. doi: 10.1007/s11120-018-0497-9. [Epub ahead of print]

    [Abstract] [Full text] [Full text PDF]

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    Proteomic composition of Nipah virus-like particles.

    Reference

    Vera-Velasco NM, García-Murria MJ, Sánchez Del Pino MM, Mingarro I, Martinez-Gil L. Proteomic composition of Nipah virus-like particles. J Proteomics. 2018 Feb 10;172:190-200. doi: 10.1016/j.jprot.2017.10.012. Epub 2017 Oct 29.

    [Abstract] [Full text] [Full text PDF]

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    Characterization of the inner membrane protein BB0173 from Borrelia burgdorferi.

    Reference

    Brock CM, Bañó-Polo M, Garcia-Murria MJ, Mingarro I, Esteve-Gasent M. Characterization of the inner membrane protein BB0173 from Borrelia burgdorferi. BMC Microbiol. 2017 Nov 22;17(1):219. doi: 10.1186/s12866-017-1127-y.

    [Abstract] [Full text] [Full text]

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    The role of hydrophobic matching on transmembrane helix packing in cells.

    Reference

    Brayan Grau, Matti Javanainen, Maria Jesús García-Murria, Waldemar Kulig, Ilpo Vattulainen, Ismael Mingarro, Luis Martínez-Gil. The role of hydrophobic matching on transmembrane helix packing in cells. Cell Stress. 1. 90-106. 10.15698/cst2017.11.111.

    [Abstract & Full text]

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    Exploring the Human-Nipah virus protein-protein interactions.

    Reference

    Martinez-Gil L, Vera-Velasco NM, Mingarro I. Exploring the Human-Nipah virus protein-protein interactions. J Virol. 2017 Nov 14;91(23). pii: e01461-17. doi: 10.1128/JVI.01461-17. Print 2017 Dec 1.

    [Abstract] [Full text]

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    N-linked glycosylation of the p24 family protein p24δ5 modulates retrograde Golgi-to-ER transport of K/HDEL ligands in Arabidopsis.

    Reference

    Pastor-Cantizano N, García-Murria MJ, Bernat-Silvestre C, Marcote MJ, Mingarro I, Aniento F. N-linked glycosylation of the p24 family protein p24δ5 modulates retrograde Golgi-to-ER transport of K/HDEL ligands in Arabidopsis. Mol Plant. 2017 Aug 7;10(8):1095-1106. doi: 10.1016/j.molp.2017.07.007. Epub 2017 Jul 19.

    [Abstract] [Full text] [Full text PDF]

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    Membrane insertion and topology of the translocon-associated protein (TRAP) gamma subunit.

    Reference

    Bañó-Polo M, Martínez-Garay CA, Grau B, Martínez-Gil L, Mingarro I. Membrane insertion and topology of the translocon-associated protein (TRAP) gamma subunit. Biochim Biophys Acta. 2017 May;1859(5):903-909. doi: 10.1016/j.bbamem.2017.01.027. Epub 2017 Jan 26.

    [Abstract] [Full text] [Full text PDF]

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    Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes.

    Selected by SEBBM (Spanish Society for Biochemistry and Molecular Biology) as “Article of the Month”

    Reference

    Andreu-Fernández V, Sancho M, Genovés A, Lucendo E, Todt F, Lauterwasser J, Funk K, Jahreis G, Pérez-Payá E, Mingarro I*, Edlich F, Orzáez M. Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):310-315. doi: 10.1073/pnas.1612322114. Epub 2016 Dec 27.

    * co-corresponding author

    [Abstract]

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    Multicentric study of the effect of pre-analytical variables in the quality of plasma samples stored in biobanks using different complementary proteomic methods.

    Reference

    Mateos J, Carneiro I, Corrales F, Elortza F, Paradela A, Del Pino MS, Iloro I, Marcilla M, Mora MI, Valero L, Ciordia S, Fernández V, Fortuño MA, García-Sánchez I, Martínez R, Muñoz MA, Rodriguez C, Doménech N; ProteoRed Spanish Biobanks Network. Multicentric study of the effect of pre-analytical variables in the quality of plasma samples stored in biobanks using different complementary proteomic methods. J Proteomics. 2017 Jan 6;150:109-120. doi: 10.1016/j.jprot.2016.09.003. Epub 2016 Sep 9.

    [Abstract] [Full text] [Full text PDF]

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    A multicentric study to evaluate the use of relative retention times in targeted proteomics.

    Reference

    Vialas V, Colomé-Calls N, Abian J, Aloria K, Alvarez-Llamas G, Antúnez O, Arizmendi JM, Azkargorta M, Barceló-Batllori S, Barderas MG, Blanco F, Casal JI, Casas V, de la Torre C, Chicano-Gálvez E, Elortza F, Espadas G, Estanyol JM, Fernandez-Irigoyen J, Fernandez-Puente P, Fidalgo MJ, Fuentes M, Gay M, Gil C, Hainard A, Hernaez ML, Ibarrola N, Kopylov AT, Lario A, Lopez JA, López-Lucendo M, Marcilla M, Marina-Ramírez A, Marko-Varga G, Martín L, Mora MI, Morato-López E, Muñoz J, Odena MA, de Oliveira E, Orera I, Ortea I, Pasquarello C, Ray KB, Rezeli M, Ruppen I, Sabidó E, Del Pino MMS, Sancho J, Santamaría E, Vazquez J, Vilaseca M, Vivanco F, Walters JJ, Zgoda VG, Corrales FJ, Canals F, Paradela A. A multicentric study to evaluate the use of relative retention times in targeted proteomics. J Proteomics. 2017 Jan 30;152:138-149. doi: 10.1016/j.jprot.2016.10.014. Epub 2016 Oct 29.

    [Abstract] [Full text] [Full text PDF]

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    NMR Investigation of Structures of G-protein Coupled Receptor Folding Intermediates.

    Reference

    Poms M, Ansorge P, Martinez-Gil L, Jurt S, Gottstein D, Fracchiolla KE, Cohen LS, Güntert P, Mingarro I, Naider F, Zerbe O. NMR Investigation of Structures of G-protein Coupled Receptor Folding Intermediates. J Biol Chem. 2016 Dec 30;291(53):27170-27186. doi: 10.1074/jbc.M116.740985. Epub 2016 Nov 18.

    [Abstract] [Full text] [Full text PDF]

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    The C-terminal domains of apoptotic BH3-only proteins mediate their insertion into distinct biological membranes.

    Reference

    Andreu-Fernandez V, García-Murria MJ, Bañó-Polo M, Martin J, Monticelli L, Orzáez M, Mingarro I. The C-terminal domains of apoptotic BH3-only proteins mediate their insertion into distinct biological membranes. J Biol Chem. 2016 Oct 7. pii: jbc.M116.733634.

    [Abstract]

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    Immunoproteomic studies on paediatric opsoclonus-myoclonus associated with neuroblastoma.

    Reference

    Torres-Vega E, Durán-Moreno M, Sánchez Del Pino M, Yáñez Y, Cañete A, Castel V, López-Cuevas R, Vílchez JJ, Dalmau J, Graus F, García Verdugo JM, Bataller L. Immunoproteomic studies on paediatric opsoclonus-myoclonus associated with neuroblastoma. J Neuroimmunol. 2016 Aug 15;297:98-102. doi: 10.1016/j.jneuroim.2016.05.015. Epub 2016 May 25.

    [Abstract] [Full text] [Full text PDF]

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    Identification of proteins that are differentially expressed in brains with Alzheimer's disease using iTRAQ labeling and tandem mass spectrometry.

    Reference

    Minjarez B, Calderón-González KG, Rustarazo ML, Herrera-Aguirre ME, Labra-Barrios ML, Rincon-Limas DE, Del Pino MM, Mena R, Luna-Arias JP. Identification of proteins that are differentially expressed in brains with Alzheimer's disease using iTRAQ labeling and tandem mass spectrometry. J Proteomics. 2016 Apr 29;139:103-21. doi: 10.1016/j.jprot.2016.03.022. Epub 2016 Mar 21.

    [Abstract] [Full text PDF] [Journal of Proteomics Index] [Full text] [Full text PDF]

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    Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation.

    Reference

    Rialdi A, Campisi L, Zhao N, Lagda AC, Pietzsch C, Ho JS, Martinez-Gil L, Fenouil R, Chen X, Edwards M, Metreveli G, Jordan S, Peralta Z, Munoz-Fontela C, Bouvier N, Merad M, Jin J, Weirauch M, Heinz S, Benner C, van Bakel H, Basler C, García-Sastre A, Bukreyev A, Marazzi I. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science. 2016 May 27;352(6289):aad7993. doi: 10.1126/science.aad7993. Epub 2016 Apr 28.

    [Abstract] [Full text]

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    Biological insertion of computationally designed short transmembrane segments.

    Selected by SBE (Spanish Biophysical Society) as “Paper of the Month”

    Reference

    Baeza-Delgado, Carlos; von Heijne, Gunnar; Marti-Renom, Marc A.; Mingarro, Ismael Biological insertion of computationally designed short transmembrane segments. Scientific Reports 6, Article number: 23397. 2016 Feb 18.

    [Full text]

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    The ER-Membrane Transport System Is Critical for Intercellular Trafficking of the NSm Movement Protein and Tomato Spotted Wilt Tospovirus.

    Reference

    Feng Z, Xue F, Xu M, Chen X, Zhao W, Garcia-Murria MJ, Mingarro I, Liu Y, Huang Y, Jiang L, Zhu M, Tao X. The ER-Membrane Transport System Is Critical for Intercellular Trafficking of the NSm Movement Protein and Tomato Spotted Wilt Tospovirus. PLoS Pathog. 2016 Feb 10;12(2):e1005443. doi: 10.1371/journal.ppat.1005443. eCollection 2016.

    [Abstract] [Full text] [Full text PDF]

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    Human peroxin PEX3 is co-translationally integrated into the ER and exits the ER in budding vesicles.

    Reference

    Mayerhofer PU, Bañó-Polo M, Mingarro I, Johnson AE. Human peroxin PEX3 is co-translationally integrated into the ER and exits the ER in budding vesicles. Traffic. 2016 Feb;17(2):117-30. doi: 10.1111/tra.12350. Epub 2015 Dec 21.

    [Abstract] [Full text] [Full text PDF]

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    Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence.

    Reference

    Garin-Muga A, Odriozola L, Martínez-Val A, Del Toro N, Martínez R, Molina M, Cantero L, Rivera R, Garrido N, Dominguez F, Sanchez Del Pino MM, Vizcaíno JA, Corrales FJ, Segura V. Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence. J Proteome Res. 2016 Nov 4;15(11):4101-4115. Epub 2016 Sep 15.

    [Abstract] [Full text] [Full text PDF]

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    Data set of the protein expression profiles of Luminal A, Claudin-low and overexpressing HER2+ breast cancer cell lines by iTRAQ labelling and tandem mass spectrometry.

    Reference

    Calderón-González KG, Valero Rustarazo ML, Labra-Barrios ML, Bazán-Méndez CI, Tavera-Tapia A, Herrera-Aguirre M, et al. Data set of the protein expression profiles of Luminal A, Claudin-low and overexpressing HER2+ breast cancer cell lines by iTRAQ labelling and tandem mass spectrometry. Data in Brief. 4: 292-301 (2015).

    [Abstract]

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    Viroporins, Examples of the Two-Stage Membrane Protein Folding Model.

    Reference

    Martinez-Gil L., Mingarro I. Viroporins, Examples of the Two-Stage Membrane Protein Folding Model. Viruses. 2015 Jun 26;7(7):3462-3482.

    [Abstract] [Abstract] [DOI] [Full text] [Full text PDF]

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    Molecular and topological membrane folding determinants of transient receptor potential vanilloid 2 channel

    Reference

    Doñate-Macian P, Bañó-Polo M, Vazquez-Ibar JL, Mingarro I*, Perálvarez-Marín A. Molecular and topological membrane folding determinants of transient receptor potential vanilloid 2 channel Biochem Biophys Res Commun. 2015 Jul 3;462(3):221-6. doi: 10.1016/j.bbrc.2015.04.120. Epub 2015 May 5.

    * co-corresponding author

    [Abstract] [Full text] [Full text PDF]

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    Prediction of a missing protein expression map in the context of the human proteome project.

    Reference

    Guruceaga E, Sánchez del Pino MM, Corrales FJ, Segura V. Prediction of a missing protein expression map in the context of the human proteome project. J Proteome Res. 2015 Mar 6;14(3):1350-60. doi: 10.1021/pr500850u. Epub 2015 Feb 5.

    [Abstract] [Full text] [Full text PDF]

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    Nobel Medicina i Fisiologia 2013: El Transport Cel·lular.

    Reference

    Mingarro I., Aniento F. Nobel Medicina i Fisiologia 2013: El Transport Cel·lular. Treballs de la Societat Catalana de Biologia (2014) 65:73.

    [Index] [Full text] [Full text PDF]

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    PStitching proteins into membranes, not sew simple.

    Reference

    Whitley P., Mingarro I. PStitching proteins into membranes, not sew simple. Biol Chem. 2014 Dec;395(12):1417-24. doi: 10.1515/hsz-2014-0205.

    [Abstract]

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    Peptides Derived from the Transmembrane Domain of Bcl-2 Proteins as Potential Mitochondrial Priming Tools.

    Reference

    Andreu-Fernandez V, Genoves A, Lee TH, Stellato M, Lucantoni F, Orzaez M, Mingarro I, Aguilar MI, Perez-Paya E. Peptides Derived from the Transmembrane Domain of Bcl-2 Proteins as Potential Mitochondrial Priming Tools. ACS Chem. Biol. (2014) 9(8):1799-811.

    [Abstract] [Abstract] [Full text] [Full text PDF]

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    Unveiling novel interactions of histone chaperone Asf1 linked to TREX-2 factors Sus1 and Thp1.

    Reference

    Pamblanco M, Oliete-Calvo P, Garcia-Oliver E, Luz Valero M, Sánchez Del Pino MM, Rodriguez-Navarro S. Unveiling novel interactions of histone chaperone Asf1 linked to TREX-2 factors Sus1 and Thp1. Nucleus (2014) 13;5(3).

    [Abstract] [Full text] [Full text PDF]

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    The Tobacco Mosaic Virus movement protein associates with but does not integrate into biological membranes.

    Selected by editors as Spotlight

    Reference

    Peiro A, Martinez-Gil L, Tamborero S, Pallas V, Sanchez-Navarro JA, Mingarro I. The Tobacco Mosaic Virus movement protein associates with but does not integrate into biological membranes. J. Virol. (2014) 88(5):3016-26.

    [Abstract] [Full text] [Full text PDF]

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    Surfing Transcriptomic Landscapes. A step beyond the annotation of chromosome 16 proteome.

    Reference

    Segura V, Medina-Aunon JA, Mora MI, Martinez-Bartolome S, Abian J, Aloria K, Antunez O, Arizmendi JM, Azkargorta M, Barcelo-Batllori S, Beaskoetxea J, Bech-Serra JJ, Blanco F, Monteiro MB, Caceres D, Canals F, Carrascal M, Casal JI, Clemente F, Colome N, Dasilva N, Diaz P, Elortza F, Fernandez-Puente P, Fuentes M, Gallardo O, Gharbi SI, Gil C, Gonzalez-Tejedo C, Hernaez ML, Lombardia M, Lopez-Lucendo M, Marcilla M, Mato JM, Mendes M, Oliveira E, Orera I, Pascual-Montano A, Prieto G, Ruiz-Romero C, Sánchez Del Pino MM, Tabas-Madrid D, Valero ML, Vialas V, Villanueva J, Albar JP, Corrales FJ. Surfing Transcriptomic Landscapes. A step beyond the annotation of chromosome 16 proteome. J. Proteome Res. (2014) 13(1):158-72.

    [Abstract] [Abstract] [Full text] [Full text PDF]

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    A transmembrane serine residue in the Rot1 protein is essential for yeast cell viability.

    Reference

    Martinez-Garay CA, Juanes MA, Igual JC, Mingarro I*, Bañó MC. A transmembrane serine residue in the Rot1 protein is essential for yeast cell viability. Biochem. J. (2014) 458(2):239-49.

    * co-corresponding author

    [Abstract] [Full text]

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    The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild.

    Reference

    Prado-Martinez J, Hernando-Herraez I, Lorente-Galdos B, Dabad M, Ramirez O, Baeza-Delgado C, Morcillo-Suarez C, Alkan C, Hormozdiari F, Raineri E, Estelle J, Fernandez-Callejo M, Valles M, Ritscher L, Schoneberg T, de la Calle-Mustienes E, Casillas S, Rubio-Acero R, Mele M, Engelken J, Caceres M, Gomez-Skarmeta JL, Gut M, Bertranpetit J, Gut IG, Abello T, Eichler EE, Mingarro I, Lalueza-Fox C, Navarro A, Marques-Bonet T. The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild. BMC Genomics (2013) 14:363.

    [Abstract] [Full text] [Full text PDF]

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    BB0172, a Borrelia burgdorferi outer membrane protein that binds integrin α3β1.

    Reference

    Wood E, Tamborero S, Mingarro I & Esteve-Gassent MD. BB0172, a Borrelia burgdorferi outer membrane protein that binds integrin α3β1. J. Bacteriol. (2013) 195(15):3320-30.

    [Abstract] [Full text] [Full text PDF]

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    Charge pair interactions in transmembrane helices and turn propensity of the connecting sequence promote helical hairpin insertion.

    Reference

    Bañó-Polo M, Martinez-Gil L, Wallner B, Nieva JL, Elofsson A & Mingarro I. Charge pair interactions in transmembrane helices and turn propensity of the connecting sequence promote helical hairpin insertion. J. Mol. Biol. (2013) 425(4):830-40.

    [Abstract] [Full text] [Full text PDF]

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    Spanish human proteome project: dissection of chromosome 16.

    Reference

    Segura V, Medina-Aunon JA, Guruceaga E, Gharbi SI, Gonzalez-Tejedo C, Sánchez del Pino MM, Canals F, Fuentes M, Casal JI, Martinez-Bartolome S, Elortza F, Mato JM, Arizmendi JM, Abian J, Oliveira E, Gil C, Vivanco F, Blanco F, Albar JP, Corrales FJ. Spanish human proteome project: dissection of chromosome 16. J. Proteome Res. (2013) 12(1):112-22.

    [Abstract] [Full text]

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    Identification of polypeptides in neurofibrillary tangles and total homogenates of brains with Alzheimer's disease by tandem mass spectrometry.

    Reference

    Minjarez B, Rustarazo ML, Sánchez del Pino MM, Gonzalez-Robles A, Sosa-Melgarejo JA, Luna-Muñoz J, Mena R, Luna-Arias JP. Identification of polypeptides in neurofibrillary tangles and total homogenates of brains with Alzheimer's disease by tandem mass spectrometry. J. Alzheimers Dis. (2013) 34(1):239-62.

    [Abstract] [Full text] [Full text PDF]

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    Structure-based statistical analysis of transmembrane helices.

    Reference

    Baeza-Delgado C., Marti-Renom M.A. & Mingarro I. Structure-based statistical analysis of transmembrane helices. Eur. Biophys. J. (2013) 42(2-3):199-207.

    [Abstract] [Full text] [Full text PDF]

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    Polar/Ionizable residues in transmembrane segments: effects on helix-helix packing.

    Reference

    Bañó-Polo M, Baeza-Delgado C, Orzaez M, Marti-Renom MA, Abad C & Mingarro I. Polar/Ionizable residues in transmembrane segments: effects on helix-helix packing. PLoS ONE (2012) 7(9):e44263.

    [Abstract] [Full text] [Full text PDF]

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    Interfacial behaviour of recombinant forms of human pulmonary surfactant protein SP-C.

    Reference

    Lukovic D., Cruz A., Gonzalez-Horta A., Almlen A., Curstedt T., Mingarro I., Perez-Gil J. Interfacial behaviour of recombinant forms of human pulmonary surfactant protein SP-C. Langmuir 28(20):7811-25.

    [Abstract] [Full text] [Full text PDF]

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    Decoding the Folding of Burkholderia glumae Lipase: Folding Intermediates En Route to Kinetic Stability.

    Reference

    Pauwels, K., Sánchez del Pino, M.M., Feller, G., and Van Gelder, P. Decoding the Folding of Burkholderia glumae Lipase: Folding Intermediates En Route to Kinetic Stability. PLoS ONE (2012) 7(5):e36999.

    [Abstract] [Full text] [Full text PDF]

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    Development of a human extracellular matrix for applications related with stem cells and tissue engineering.

    Reference

    Escobedo-Lucea C, Ayuso-Sacido A, Xiong C, Prado-López S, del Pino MS, Melguizo D, Bellver-Estellés C, Gonzalez-Granero S, Valero ML, Moreno R, Burks DJ, Stojkovic M. Development of a human extracellular matrix for applications related with stem cells and tissue engineering. Stem Cell Rev. 2012 Mar;8(1):170-83. doi: 10.1007/s12015-011-9270-6.

    [Abstract] [Full text] [Full text PDF]

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    Extracellular vesicles from parasitic helminths contain specific excretory/secretory proteins and are internalized in intestinal host cells.

    Reference

    Marcilla A, Trelis M, Cortés A, Sotillo J, Cantalapiedra F, Minguez MT, Valero ML, Sánchez del Pino MM, Muñoz-Antoli C, Toledo R, Bernal D. Extracellular vesicles from parasitic helminths contain specific excretory/secretory proteins and are internalized in intestinal host cells. PLoS One. 2012;7(9):e45974. doi: 10.1371/journal.pone.0045974. Epub 2012 Sep 24.

    [Abstract] [Full text] [Full text PDF]

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    Proteomic analysis of the pinworm Syphacia muris (Nematoda: Oxyuridae), a parasite of laboratory rats.

    Reference

    Sotillo J, Trelis M, Cortés A, Valero ML, del Pino MS, Guillermo Esteban J, Marcilla A, Toledo R. Proteomic analysis of the pinworm Syphacia muris (Nematoda: Oxyuridae), a parasite of laboratory rats. Parasitol Int. 2012 Dec;61(4):561-4. doi: 10.1016/j.parint.2012.05.004. Epub 2012 May 11.

    [Abstract] [Full text] [Full text PDF]

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    Membrane integration of poliovirus 2B viroporin.

    Reference

    Martinez-Gil L., Bano-Polo M., Redondo N., Sanchez-Martinez S., Nieva J.L, Carrasco L. & Mingarro I. Membrane integration of poliovirus 2B viroporin. J. Virol. (2011) 85(21):11315-24.

    [Abstract] [Full text] [Full text PDF]

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    Membrane protein integration into the ER.

    Reference

    Martinez-Gil L., Sauri A., Marti-Renom M.A. & Mingarro I. Membrane protein integration into the ER. FEBS J. (2011) 278(20):3846-58.

    [Abstract] [Full text]

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    Membrane insertion and topology of the TRanslocating chain-Associating Membrane protein (TRAM).

    Reference

    Tamborero S., Vilar M., Martinez-Gil L., Johnson A.E. & Mingarro I. Membrane insertion and topology of the TRanslocating chain-Associating Membrane protein (TRAM). J. Mol. Biol. (2011) 406(4):571-82.

    [Abstract] [Full text] [Full text PDF]

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    N-Glycosylation efficiency is determined by the distance to the C-terminus and the amino acid preceding an Asn-Ser-Thr sequon.

    Reference

    Bañó-Polo M., Baldin F., Tamborero S., Marti-Renom M.A. & Mingarro I. N-Glycosylation efficiency is determined by the distance to the C-terminus and the amino acid preceding an Asn-Ser-Thr sequon. Protein Sci. (2011) 20(1):179-86.

    [Abstract] [Full text] [Full text PDF]

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    Phosphorylation of AIB1 at Mitosis Is Regulated by CDK1 / CYCLIN B.

    Reference

    Ferrero, M.; Ferragud, J.; Orlando, L.; Valero, L.; Sánchez del Pino, M.; Farràs, R.; Font de Mora, J. Phosphorylation of AIB1 at Mitosis Is Regulated by CDK1 / CYCLIN B. PLoS ONE 6(12): e28602. doi:10.1371/journal.pone.0028602.

    [Abstract] [Full text PDF]

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    Simple chemical tools to expand the range of proteomics applications.

    Reference

    García-Murria MJ, Valero ML, Sánchez del Pino MM. Simple chemical tools to expand the range of proteomics applications. J Proteomics. 2011 Feb 1;74(2):137-50. doi: 10.1016/j.jprot.2010.11.002. Epub 2010 Nov 11.

    [Abstract] [Full text] [Full text PDF]

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    Small peptides released from muscle glycolytic enzymes during dry-cured ham processing.

    Reference

    Mora L, Valero ML, Sánchez Del Pino MM, Sentandreu MA, Toldrá F. Small peptides released from muscle glycolytic enzymes during dry-cured ham processing. J Proteomics. 2011 Apr 1;74(4):442-50. doi: 10.1016/j.jprot.2010.12.008. Epub 2011 Jan 13.

    [Abstract] [Full text] [Full text PDF]

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    Zygocotyle lunata: Proteomic analysis of the adult stage.

    Reference

    Sotillo J, Valero ML, Sánchez del Pino MM, Fried B, Esteban JG, Marcilla A, Toledo R. Zygocotyle lunata: Proteomic analysis of the adult stage. Exp Parasitol. 2011 Jun;128(2):133-7. doi: 10.1016/j.exppara.2011.02.014. Epub 2011 Feb 18.

    [Abstract] [Full text] [Full text PDF]

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    Palmitoylation of pulmonary surfactant protein SP-C is critical for its functional cooperation with SP-B to sustain compression/expansion dynamics in cholesterol-containing surfactant films.

    Reference

    Baumgart F., Ospina O.L., Mingarro I., Rodriguez-Crespo I., Perez-Gil J. Palmitoylation of pulmonary surfactant protein SP-C is critical for its functional cooperation with SP-B to sustain compression/expansion dynamics in cholesterol-containing surfactant films. Biophys. J. (2010) 99(10):3234-43.

    [Abstract] [Full text] [Full text PDF]

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    Membrane insertion and biogenesis of the Turnip Crinkle Virus p9 movement protein.

    Reference

    Martinez-Gil L., Johnson A.E., Mingarro I. Membrane insertion and biogenesis of the Turnip Crinkle Virus p9 movement protein. J. Virol. (2010) 84(11):5520-7.

    [Abstract] [Full text] [Full text PDF]

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    Membrane topology of gp41 and amyloid precursor protein: interfering transmembrane interactions as potential targets for HIV and Alzheimer treatment.

    Reference

    Abad C., Martinez-Gil L., Tamborero S., Mingarro I. Membrane topology of gp41 and amyloid precursor protein: interfering transmembrane interactions as potential targets for HIV and Alzheimer treatment. BBA-Biomembranes. (2009) 1788(10):2132-41.

    [Abstract] [Full text] [Full text PDF]

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    Plant virus cell-to-cell movement is not dependent on the transmembrane disposition of its movement protein.

    Reference

    Martinez-Gil L., Sánchez-Navarro J.A., Cruz A., Pallas V., Perez-Gil J., Mingarro I. Plant virus cell-to-cell movement is not dependent on the transmembrane disposition of its movement protein. J. Virol. (2009) 83(11):5535-43.

    [Abstract] [Full text] [Full text PDF]

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    Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers.

    Reference

    Vilar M., Charalampopoulos I., Kenchappa R.S., Simi A., Reversi A., Choi S., Bothwell M., Mingarro I., Friedman W., Schiavo G., Bastiaens P.I.H., Verveer P.J., Carter B.D., Ibanez C.F. Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron (2009) 62(1):72-83.

    [Abstract] [Full text] [Full text PDF]

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    Viral membrane protein topology is dictated by multiple determinants in its sequence.

    Reference

    Sauri A., Tamborero S., Martinez-Gil L., Johnson A.E., Mingarro I. Viral membrane protein topology is dictated by multiple determinants in its sequence. J. Mol. Biol. (2009) 387(1):113-28.

    [Abstract] [Full text] [Full text PDF]

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    Binding of water-soluble, globular proteins to anionic model membranes.

    Reference

    Torrens F., Castellano G., Campos A., Abad C. Binding of water-soluble, globular proteins to anionic model membranes. J. Mol. Struct. (2009) 924-6:274-84.

    [Full text] [Full text PDF]

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    The surfactant peptide KL4 sequence is inserted with a transmembrane orientation into the endoplasmic reticulum membrane.

    Reference

    Martinez-Gil L., Perez-Gil J., Mingarro I. The surfactant peptide KL4 sequence is inserted with a transmembrane orientation into the endoplasmic reticulum membrane. Biophys. J. (2008) 95(6):L36-8.

    [Full text] [Full text PDF]

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    Synthetic pulmonary surfactant preparations: new developments and future trends.

    Reference

    Mingarro I.*, Lukovic D., Vilar M., Perez-Gil J. Synthetic pulmonary surfactant preparations: new developments and future trends. Curr. Med. Chem. (2008) 15(4):393-403.

    * co-corresponding author

    [Abstract]

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    Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF.

    Reference

    Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G. Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF. J. Neurosci. (2008) 28:39-49.

    [Abstract] [Full text] [Full text PDF]

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    Membrane insertion and topology of the p7B movement protein of Melon Necrotic Spot Virus (MNSV).

    Reference

    Martinez-Gil L., Sauri A., Vilar M., Pallas V., Mingarro I. Membrane insertion and topology of the p7B movement protein of Melon Necrotic Spot Virus (MNSV). Virology. (2007) 367:348-357.

    [Abstract] [Full text] [Full text PDF]

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    Negatively cooperative binding of melittin to neutral phospholipid vesicles.

    Reference

    Torrens F., Castellano G., Campos A., Abad C. Negatively cooperative binding of melittin to neutral phospholipid vesicles. J. Mol. Struct. (2007) 834-836:216-228.

    [Full text] [Full text PDF]

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    Sec61α and TRAM are Sequentially Adjacent to a Nascent Viral Membrane Protein during its ER Integration.

    Reference

    Sauri A., McCormick PJ., Johnson AE., Mingarro I. Sec61α and TRAM are Sequentially Adjacent to a Nascent Viral Membrane Protein during its ER Integration. J. Mol. Biol. (2007) 366:366-374.

    [Abstract] [Full text] [Full text PDF]

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    RNA-binding properties and membrane insertion of Melon necrotic spot virus (MNSV) double gene block movement proteins.

    Reference

    Navarro J.A.,Genoves A., Climent J, Sauri A., Martinez-Gil L., Mingarro I., Pallas V. RNA-binding properties and membrane insertion of Melon necrotic spot virus (MNSV) double gene block movement proteins. Virology. (2006) 356:57-67.

    [Abstract] [Full text] [Full text PDF]

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    Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion.

    Reference

    Gomara, M.J., Lorizate, M., Huarte, N., Mingarro I., Perez-Paya, E. & Nieva, J.L. Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion. FEBS Lett. (2006) 580(11): 2561-2566.

    [Full text] [Full text PDF]

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    Production and characterisation of recombinant forms of human pulmonary surfactant protein C (SP-C): Structure and surface activity.

    Reference

    Lukovic, D., Plasencia, I., Taberner, F.J., Salgado, J., Calvete, J.J., Perez-Gil, J. & Mingarro I. Production and characterisation of recombinant forms of human pulmonary surfactant protein C (SP-C): Structure and surface activity. Biochim. Biophys. Acta. (2006) 1758(4): 509-18.

    [Full text] [Full text PDF]

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    Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores.

    Reference

    García-Sáez, A. J., Coraiola, M., Dalla Serra, M., Mingarro, I., Müller, P. & Salgado, J. Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores. FEBS J. (2006) 273 (5): 971-981.

    [Abstract]

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    Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis.

    Reference

    Malet, G., A.G. Martín, M. Orzáez, M.J. Vicent, I. Masip, G. Sanclimens, A. Ferrer-Montiel, I. Mingarro, A. Messeguer, H.O. Fearnhead & E. Pérez-Payá. Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis. Cell Death Differ. (2006) 13(9): 1523-1532.

    [Full text] [Full text PDF]

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    Transient structural ordering of the RNA-binding domain of carnation mottle virus p7 movement protein modulates nucleic acid binding.

    Reference

    Vilar, M., A. Sauri, J.F. Marcos, I. Mingarro* & E. Pérez-Payá. Transient structural ordering of the RNA-binding domain of carnation mottle virus p7 movement protein modulates nucleic acid binding. Chembiochem. (2005) 6 (8): 1391-1396.

    * co-corresponding author

    [Abstract] [Full text] [Full text PDF]

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    Double-spanning plant viral movement protein integration into the ER membrane is SRP-dependent, translocon-mediated, and concerted.

    Reference

    Sauri, A., S. Saksena, J. Salgado, A.E. Johnson & I. Mingarro. Double-spanning plant viral movement protein integration into the ER membrane is SRP-dependent, translocon-mediated, and concerted. J. Biol. Chem. (2005) 280 (27): 25907-25912.

    [Abstract] [Full text] [Full text PDF]

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    Mutational analysis of the RNA-binding domain of the Prunus necrotic ringspot virus (PNRSV) movement protein reveals its requirement for cell-to-cell movement.

    Reference

    Herranz, M.C., J.A. Sanchez-Navarro, A. Sauri, I. Mingarro & V. Pallas. Mutational analysis of the RNA-binding domain of the Prunus necrotic ringspot virus (PNRSV) movement protein reveals its requirement for cell-to-cell movement. Virology. (2005) 339 (1): 31-41.

    [Abstract] [Full text] [Full text PDF]

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    Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins.

    Reference

    García-Sáez, A.J., M. Coraiola, M. Dalla Serra, I. Mingarro, G. Menestrina & J. Salgado. Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins. Biophys. J. (2005) 88 (6): 3976-3990.

    [Abstract] [Full text] [Full text PDF]

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    Influence of hydrophobic matching on association of model transmembrane fragments containing a minimised glycophorin A dimerisation motif.

    Reference

    Orzáez, M., D. Lukovic, C. Abad, E. Pérez-Payá & I. Mingarro. Influence of hydrophobic matching on association of model transmembrane fragments containing a minimised glycophorin A dimerisation motif. FEBS Lett. (2005) 579 (7): 1633-1638.

    [Abstract] [Full text] [Full text PDF]

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    Identification from a positional scanning peptoid library of in vivo active compounds that neutralize bacterial endotoxins.

    Reference

    Mora, P., I. Masip, N. Cortes, R. Marquina, R. Merino, J. Merino, T. Carbonell, I. Mingarro, A. Messeguer, E. Pérez-Payá. Identification from a positional scanning peptoid library of in vivo active compounds that neutralize bacterial endotoxins. J. Med. Chem. (2005) 48 (4): 1265-1268.

    [Abstract] [Full text] [Full text PDF]

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    Influence of proline residues in transmembrane helix packing.

    Reference

    Orzáez, M., J. Salgado, A., Giménez-Giner, E. Pérez-Payá & I. Mingarro. Influence of proline residues in transmembrane helix packing. J. Mol. Biol. (2004) 335: 631-640.

    [Abstract] [Full text] [Full text PDF]

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    Membrane insertion fragments of Bcl-xL Bax and Bid.

    Reference

    García-Sáez,A.J., I. Mingarro, E. Pérez-Payá & J. Salgado. Membrane insertion fragments of Bcl-xL Bax and Bid. Biochemistry. (2004) 34: 10930-10943.

    [Abstract] [Full text] [Full text PDF]

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    Helix-helix packing in transmembrane fragments.

    Reference

    Orzáez, M., F. Taberner, E. Pérez-Payá & I. Mingarro. Helix-helix packing in transmembrane fragments. in Methods in Proteome and Protein Analysis, R.M. Kamp, J.J. Calvete & T. Choli-Papadopoulou, eds. Series: Principles and Practice. Springer-Verlag, Berlin, pp. 1-14 (2004).

    [Abstract]

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    Roles of a conserved proline in the internal fusion peptide of Ebola glycoprotein.

    Reference

    Gomara, M.J., P. Mora, I. Mingarro & J.L. Nieva. Roles of a conserved proline in the internal fusion peptide of Ebola glycoprotein. FEBS Lett. (2004) 569: 261-266.

    [Abstract] [Full text] [Full text PDF]

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    Ionic self-complementarity induces amyloid-like fibril formation in an isolated domain of a plant copper metallochaperone protein.

    Reference

    Mira, H., M. Vilar, V. Esteve, M. Martinell, M.J. Kogan, E. Giralt, D. Salom, I. Mingarro, L. Penarrubia & E. Peréz-Payá. Ionic self-complementarity induces amyloid-like fibril formation in an isolated domain of a plant copper metallochaperone protein. BMC Struct. Biol. (2004) 4: 7.

    [Abstract] [Full text] [Full text PDF]

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    Stabilisation of mixed peptide/lipid complexes in selective antifungal hexapeptides.

    Reference

    Lopez-Garcia, B., J.F. Marcos, C. Abad, E. & Perez-Paya. Stabilisation of mixed peptide/lipid complexes in selective antifungal hexapeptides. Biochim. Biophys. Acta. (2004) 1660: 131-137.

    [Abstract] [Full text] [Full text PDF]

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    The structural plasticity of the C terminus of p21Cip1 is a determinant for target protein recognition.

    Reference

    Esteve, V., N. Canela, A. Rodriguez-Vilarrupla, R. Aligue, N. Agell, I. Mingarro I, O. Bachs & E. Pérez-Payá. The structural plasticity of the C terminus of p21Cip1 is a determinant for target protein recognition. Chembiochem. (2003) 4: 863-869.

    [Abstract] [Full text] [Full text PDF]

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    Calcium-dependent conformational changes of membrane-bound Ebola fusion peptide drive vesicle fusion.

    Reference

    Suarez, T., M.J. Gomara, F.M. Goñi, I. Mingarro, A. Muga, E. Peréz-Payá & J.L. Nieva. Calcium-dependent conformational changes of membrane-bound Ebola fusion peptide drive vesicle fusion. FEBS Lett. (2003) 535: 23-28.

    [Abstract] [Full text] [Full text PDF]

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    Lipase activation by trapping of conformers in the presence of interfaces in biotechnological reactions.

    Reference

    González-Navarro, H., C. Abad, M.C. Bañó & I. Mingarro. Lipase activation by trapping of conformers in the presence of interfaces in biotechnological reactions. RRD Biotech. Bioeng. (2003) 5: 203-215.

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    Long-chain fatty acyl-CoA esters induce lipase activation in the absence of a water-lipid interface.

    Reference

    Bañó, M.C., H. González-Navarro & C. Abad. Long-chain fatty acyl-CoA esters induce lipase activation in the absence of a water-lipid interface. Biochim. Biophys. Acta. (2003) 1632: 55-61.

    [Abstract] [Full text] [Full text PDF]

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    Peptides in apoptosis research.

    Reference

    Salgado, J., A.J. García-Sáez, G. Malet, I. Mingarro & E. Pérez-Payá. Peptides in apoptosis research. J. Peptide Sci. (2002) 8: 543-560.

    [Abstract] [Full text] [Full text PDF]

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    Insertion and topology of a plant viral movement protein in the endoplasmic reticulum membrane.

    Reference

    Vilar, M., A. Sauri ,M. Monne, J.F. Marcos, G. von Heijne, E. Perez-Payá & I. Mingarro. Insertion and topology of a plant viral movement protein in the endoplasmic reticulum membrane. J. Biol. Chem. (2002) 277: 23447-23452.

    [Abstract] [Full text] [Full text PDF]

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    The amphipathic peptide melittin as a tool to study the membrane-dependent activation of tissue transglutaminase.

    Reference

    Pérez-Payá, E., C. Ferrándiz & C. Abad. The amphipathic peptide melittin as a tool to study the membrane-dependent activation of tissue transglutaminase. Lett. Pept. Sci. (2001) 8: 69-76.

    [DOI] [Abstract] [Full text PDF]

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    The closed/open model for lipase activation. Addressing intermediate active forms of fungal enzymes by trapping of conformers in water-restricted environments.

    Reference

    González-Navarro, H., M.C. Bañó & C. Abad. The closed/open model for lipase activation. Addressing intermediate active forms of fungal enzymes by trapping of conformers in water-restricted environments. Biochemistry. (2001) 40: 3174-3183.

    [Abstract] [Abstract] [Full text] [Full text PDF]

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    Membrane-bound structure and alignment of antimicrobial β-sheet peptide gramicidin S derived from angular and distance constraints by solid state 19F-NMR.

    Reference

    Salgado, J., S.L. Grage, L.H. Kondejewski, R. Hodges, R.N. McElhaney & A.S. Ulrich. Membrane-bound structure and alignment of antimicrobial β-sheet peptide gramicidin S derived from angular and distance constraints by solid state 19F-NMR. J. Biomol. NMR. (2001) 21: 191-208.

    [Abstract]

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    Different conformations of nascent polypeptides during translocation across the ER membrane.

    Reference

    Mingarro, I., I.M. Nilsson, P. Whitley & G. von Heijne. Different conformations of nascent polypeptides during translocation across the ER membrane. BMC Cell Biology. (2000) 1: 1-8.

    [Abstract] [Full text] [Full text PDF]

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    Identification of peptides that neutalize bacterial endotoxins using β-hairpin conformationally restricted libraries.

    Reference

    González-Navarro, H., P. Mora, M. Pastor, L. Serrano, I. Mingarro & E. Pérez-Payá. Identification of peptides that neutalize bacterial endotoxins using β-hairpin conformationally restricted libraries. Mol. Divers. (2000) 5: 117-27.

    [Abstract]

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    Influence of the C-terminus of Glycophorin A transmembrane fragment on the dimerization process.

    Reference

    Orzáez, M., E. Pérez-Payá & I. Mingarro. Influence of the C-terminus of Glycophorin A transmembrane fragment on the dimerization process. Protein Sci. (2000) 9: 1246-53.

    [Abstract] [Full text] [Full text PDF]

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    Distant downstream sequence determinants can control N-tail translocation during protein insertion into the endoplasmic reticulum membrane.

    Reference

    Nilsson, I., S. Witt, H. Kiefer, I. Mingarro & G. von Heijne. Distant downstream sequence determinants can control N-tail translocation during protein insertion into the endoplasmic reticulum membrane. J. Biol. Chem. (2000) 275: 6207-6213.

    [Abstract] [Full text] [Full text PDF]

Ismael’s pre-PI publications

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    Membrane protein assembly.

    Reference

    Mingarro, I., de Gier J.W., von Heijne, G., Braun P. & Whitley, P. Membrane protein assembly. Biomembrane Structures (Biomedical and Health Research, vol. 20) P.I. Haris and D. Chapman (Eds.) IOS Press (1998) 228-44.

    [Book]

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    Membrane protein engineering.

    Reference

    Mingarro, I., von Heijne, G. & Whitley, P. Membrane protein engineering. Trends in Biotechnol. (1997) 15: 432-7.

    [Abstract] [Full text] [Full text PDF]

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    Helix-helix packing in a membrane-like environment.

    Reference

    Mingarro, I., Elofsson, A. & von Heijne, G. Helix-helix packing in a membrane-like environment. J. Mol. Biol (1997) 272: 633-41.

    [Full text PDF] [Stockholm University] [Academia.edu] [Researchgate]

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    Ala-insertion scanning mutagenesis of the glycophorin A transmembrane helix.

    Reference

    Mingarro, I., Whitley, P., Lemmon, M.A. & von Heijne, G. Ala-insertion scanning mutagenesis of the glycophorin A transmembrane helix. Protein Sci. (1996) 5: 1339-41.

    [Abstract] [Full text] [Full text PDF]

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    Molecular bioimprinting-based trapping of different lipase conformers in water-restricted media.

    Reference

    Mingarro, I., González-Navarro, H. & Braco, L. Molecular bioimprinting-based trapping of different lipase conformers in water-restricted media. Biochemistry (1996) 35: 9935-44.

    [Abstract] [Abstract] [Full text] [Full text PDF]

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    Activation of bee venom phospholipase A2 through a peptide-enzyme complex.

    Reference

    Mingarro, I., Pérez-Payá E., Pinilla, C., Appel, J. R., Houghten, R. A. & Blondelle, S. E. Activation of bee venom phospholipase A2 through a peptide-enzyme complex. FEBS Lett. (1995) 372: 131-4.

    [Abstract] [Full text] [Full text PDF]

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    Interfacial activation-based molecular bioimprinting of lipolytic enzymes.

    Reference

    Mingarro, I., Abad, C. & Braco, L. Interfacial activation-based molecular bioimprinting of lipolytic enzymes. Proc. Natl. Acad. Sci. USA (1995) 92: 3308-12.

    [Abstract] [Full text] [Full text PDF]

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    Direct HPLC monitoring of lipase activity in reverse micellar media.

    Reference

    Mingarro I. González-Navarro H. & Braco L. Direct HPLC monitoring of lipase activity in reverse micellar media. Journal of liquid chromatography 01/1995; 18(2):235-244.

    [Researchgate]

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    Characterization of acylating and deacylating activities of an extracellular phospholipase A2 in a water-restricted environment.

    Reference

    Mingarro, I., Abad, C. & Braco, L. Characterization of acylating and deacylating activities of an extracellular phospholipase A2 in a water-restricted environment. Biochemistry (1994) 33: 4652-60.

    [Abstract]

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    Site specificity of pea histone acetyltransferase B in vitro.

    Reference

    Mingarro I., Sendra R., Salvador ML. & Franco L. Site specificity of pea histone acetyltransferase B in vitro. J. Biol. Chem. (1993) 268: 13248-52.

    [Abstract] [Full text] [Full text PDF]