2018

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    Proteomic composition of Nipah virus-like particles.

    Reference

    Vera-Velasco NM, García-Murria MJ, Sánchez Del Pino MM, Mingarro I, Martinez-Gil L. Proteomic composition of Nipah virus-like particles. J Proteomics. 2018 Feb 10;172:190-200. doi: 10.1016/j.jprot.2017.10.012. Epub 2017 Oct 29.

    [Abstract] [Full text] [Full text PDF]

2017

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    Characterization of the inner membrane protein BB0173 from Borrelia burgdorferi.

    Reference

    Brock CM, Bañó-Polo M, Garcia-Murria MJ, Mingarro I, Esteve-Gasent M. Characterization of the inner membrane protein BB0173 from Borrelia burgdorferi. BMC Microbiol. 2017 Nov 22;17(1):219. doi: 10.1186/s12866-017-1127-y.

    [Abstract] [Full text] [Full text]

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    The role of hydrophobic matching on transmembrane helix packing in cells.

    Reference

    Brayan Grau, Matti Javanainen, Maria Jesús García-Murria, Waldemar Kulig, Ilpo Vattulainen, Ismael Mingarro, Luis Martínez-Gil. The role of hydrophobic matching on transmembrane helix packing in cells. Cell Stress. 1. 90-106. 10.15698/cst2017.11.111.

    [Abstract & Full text]

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    Exploring the Human-Nipah virus protein-protein interactions.

    Reference

    Martinez-Gil L, Vera-Velasco NM, Mingarro I. Exploring the Human-Nipah virus protein-protein interactions. J Virol. 2017 Nov 14;91(23). pii: e01461-17. doi: 10.1128/JVI.01461-17. Print 2017 Dec 1.

    [Abstract] [Full text]

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    Identification and validation of uterine stimulant methylergometrine as a potential inhibitor of caspase-1 activation.

    Reference

    García-Laínez G, Sancho M, García-Bayarri V, Orzáez M. Identification and validation of uterine stimulant methylergometrine as a potential inhibitor of caspase-1 activation. Apoptosis. 2017 Oct;22(10):1310-1318. doi: 10.1007/s10495-017-1405-z.

    [Abstract] [Full text] [Full text PDF]

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    Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles.

    Reference

    García-Fernández A, García-Laínez G, Ferrándiz ML, Aznar E, Sancenón F, Alcaraz MJ, Murguía JR, Marcos MD, Martínez-Máñez R, Costero AM, Orzáez M. Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles. J Control Release. 2017 Feb 28;248:60-70. doi: 10.1016/j.jconrel.2017.01.002. Epub 2017 Jan 6.

    [Abstract] [Full text] [Full text PDF]

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    Membrane insertion and topology of the translocon-associated protein (TRAP) gamma subunit.

    Reference

    Bañó-Polo M, Martínez-Garay CA, Grau B, Martínez-Gil L, Mingarro I. Membrane insertion and topology of the translocon-associated protein (TRAP) gamma subunit. Biochim Biophys Acta. 2017 May;1859(5):903-909. doi: 10.1016/j.bbamem.2017.01.027. Epub 2017 Jan 26.

    [Abstract] [Full text] [Full text PDF]

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    Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes.

    Selected by SEBBM (Spanish Society for Biochemistry and Molecular Biology) as “Article of the Month”

    Reference

    Andreu-Fernández V, Sancho M, Genovés A, Lucendo E, Todt F, Lauterwasser J, Funk K, Jahreis G, Pérez-Payá E, Mingarro I*, Edlich F, Orzáez M. Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):310-315. doi: 10.1073/pnas.1612322114. Epub 2016 Dec 27.

    * co-corresponding author

    [Abstract] [Full text PDF]

2016

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    NMR Investigation of Structures of G-protein Coupled Receptor Folding Intermediates.

    Reference

    Poms M, Ansorge P, Martinez-Gil L, Jurt S, Gottstein D, Fracchiolla KE, Cohen LS, Güntert P, Mingarro I, Naider F, Zerbe O. NMR Investigation of Structures of G-protein Coupled Receptor Folding Intermediates. J Biol Chem. 2016 Dec 30;291(53):27170-27186. doi: 10.1074/jbc.M116.740985. Epub 2016 Nov 18.

    [Abstract] [Full text] [Full text PDF]

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    The C-terminal domains of apoptotic BH3-only proteins mediate their insertion into distinct biological membranes.

    Reference

    Andreu-Fernandez V, García-Murria MJ, Bañó-Polo M, Martin J, Monticelli L, Orzáez M, Mingarro I. The C-terminal domains of apoptotic BH3-only proteins mediate their insertion into distinct biological membranes. J Biol Chem. 2016 Oct 7. pii: jbc.M116.733634.

    [Abstract] [Full text PDF]

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    Biological insertion of computationally designed short transmembrane segments.

    Selected by SBE (Spanish Biophysical Society) as “Paper of the Month”

    Reference

    Baeza-Delgado, Carlos; von Heijne, Gunnar; Marti-Renom, Marc A.; Mingarro, Ismael Biological insertion of computationally designed short transmembrane segments. Scientific Reports 6, Article number: 23397. 2016 Feb 18.

    [Full text]

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    Human peroxin PEX3 is co-translationally integrated into the ER and exits the ER in budding vesicles.

    Reference

    Mayerhofer PU, Bañó-Polo M, Mingarro I, Johnson AE. Human peroxin PEX3 is co-translationally integrated into the ER and exits the ER in budding vesicles. Traffic. 2016 Feb;17(2):117-30. doi: 10.1111/tra.12350. Epub 2015 Dec 21.

    [Abstract] [Full text] [Full text PDF]

2015

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    Apaf1 inhibition promotes cell recovery from apoptosis.

    Reference

    Gortat A, Sancho M, Mondragón L, Messeguer À, Pérez-Payá E, Orzáez M. Apaf1 inhibition promotes cell recovery from apoptosis. Protein Cell. 2015 Nov;6(11):833-43. doi: 10.1007/s13238-015-0200-2. Epub 2015 Sep 11.

    [Abstract] [Full text] [Full text PDF]

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    Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles.

    Reference

    de la Torre C, Mondragón L, Coll C, García-Fernández A, Sancenón F, Martínez-Máñez R, Amorós P, Pérez-Payá E, Orzáez M. Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles. Chemistry. 2015 Oct 26;21(44):15506-10.

    [DOI] [Full text] [Full text PDF]

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    Viroporins, Examples of the Two-Stage Membrane Protein Folding Model.

    Reference

    Martinez-Gil L., Mingarro I. Viroporins, Examples of the Two-Stage Membrane Protein Folding Model. Viruses. 2015 Jun 26;7(7):3462-3482.

    [Abstract] [Abstract] [DOI] [Full text] [Full text PDF]

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    Molecular and topological membrane folding determinants of transient receptor potential vanilloid 2 channel

    Reference

    Doñate-Macian P, Bañó-Polo M, Vazquez-Ibar JL, Mingarro I*, Perálvarez-Marín A. Molecular and topological membrane folding determinants of transient receptor potential vanilloid 2 channel Biochem Biophys Res Commun. 2015 Jul 3;462(3):221-6. doi: 10.1016/j.bbrc.2015.04.120. Epub 2015 May 5.

    * co-corresponding author

    [Abstract] [Full text] [Full text PDF]

2014

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    Cathepsin-B induced controlled release from peptide-capped mesoporous silica nanoparticles.

    Reference

    de la Torre C, Mondragón L, Coll C, Sancenón F, Marcos MD, Martínez-Máñez R, Amorós P, Pérez-Payá E, Orzáez M. Cathepsin-B induced controlled release from peptide-capped mesoporous silica nanoparticles. Chemistry. 2014 Nov 17;20(47):15309-14. doi: 10.1002/chem.201404382. Epub 2014 Oct 10.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.

    Reference

    Orzáez M, Sancho M, Marchán S, Mondragón L, Montava R, Valero JG, Landeta O, Basañez G, Carbajo RJ, Pineda-Lucena A, Bujons J, Moure A, Messeguer A, Lagunas C, Herrero C, Pérez-Payá E. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One. 2014; 9(10): e110979.

    [Abstract] [Full text] [Full text PDF]

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    Peptides Derived from the Transmembrane Domain of Bcl-2 Proteins as Potential Mitochondrial Priming Tools.

    Reference

    Andreu-Fernandez V, Genoves A, Lee TH, Stellato M, Lucantoni F, Orzaez M, Mingarro I, Aguilar MI, Perez-Paya E. Peptides Derived from the Transmembrane Domain of Bcl-2 Proteins as Potential Mitochondrial Priming Tools. ACS Chem. Biol. (2014) 9(8):1799-811.

    [Abstract] [Abstract] [Full text] [Full text PDF]

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    A transmembrane serine residue in the Rot1 protein is essential for yeast cell viability.

    Reference

    Martinez-Garay CA, Juanes MA, Igual JC, Mingarro I*, Bañó MC. A transmembrane serine residue in the Rot1 protein is essential for yeast cell viability. Biochem. J. (2014) 458(2):239-49.

    * co-corresponding author

    [Abstract] [Full text]