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  • MEMBDEATH: Hacia un nuevo enfoque terapéutico
2026
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    Cholesterol promotes the formation of dimers and oligomers of the receptor tyrosine kinase ROR1.

    Reference

    Ward A, Baeza-Ballesteros LJ, Schuck R, García-Murria MJ, Lamichhane R, Mingarro I, Barrera FN. Cholesterol promotes the formation of dimers and oligomers of the receptor tyrosine kinase ROR1. Journal of Biological Chemistry, Volume 302, Issue 1, 2026; 302(1):111000, ISSN 0021-9258.

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2025
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    The sequence and structural integrity of the SARS-CoV-2 Spike protein transmembrane domain is crucial for viral entry.

    Reference

    Ortiz-Mateu J, Belda D, Avilés-Alía AI, Alonso-Romero J, García-Murria MJ, Mingarro I, Geller R, Martinez-Gil L. The sequence and structural integrity of the SARS-CoV-2 Spike protein transmembrane domain is crucial for viral entry. Commun Biol. 2025 Nov 17;8(1):1579.

    [DOI] [PMID] [PMC] [Full text] [Full text PDF]

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    Structural insights into SARS-CoV-2 nonstructural protein 4 (nsp4) biogenesis.

    Reference

    Acosta-Cáceres JM, Lolicato F, Gadea-Salom L, Ortiz-Mateu J, Belda D, Martínez-Gil L, García-Murria MJ, Mingarro I. Structural insights into SARS-CoV-2 nonstructural protein 4 (nsp4) biogenesis. Protein Sci. 2025 Nov;34(11):e70355.

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    Decoding chromosomal instability insights in CRC by integrating omics and patient-derived organoids.

    Reference

    Papaccio, F., Cabeza-Segura, M., García-Micó, B. et al. Decoding chromosomal instability insights in CRC by integrating omics and patient-derived organoids. J Exp Clin Cancer Res 44, 77 (2025).

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    Differential Proteomic Profile in the Amniotic Fluid of Pregnancies with Trisomy 21.

    Reference

    Rodríguez-López R, Palomares YH, Ferrer FG, Bolufer IF, Luján CG, Alcalá OZ, Cabrera N, Rustarazo MLV, Colom JE, Velasco Esteban MJ, Marcaida Benito G, Secaduras Mora A, Sánchez del Pino MM. Differential Proteomic Profile in the Amniotic Fluid of Pregnancies with Trisomy 21. J Biomed Res Environ Sci. 2025; 6:532-44. 10.37871/jbres2108.

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    Sequence-dependent scale for translocon-mediated insertion of interfacial helices in membranes.

    SBE article of the month

    Reference

    Brayan Grau et al. Sequence-dependent scale for translocon-mediated insertion of interfacial helices in membranes. Sci. Adv.11,eads6804(2025).DOI:10.1126/sciadv.ads6804

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2024
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    Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain.

    Reference

    Leiva, D., Lucendo, E., García-Jareño, A.B. et al. Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain. Oncogenesis 13, 14 (2024). PMID: 38670940; PMCID: PMC11052995.

    [DOI] [Abstract] [Full text] [Full text] [Full text PDF] [Full text PDF]

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    Experimental and computational approaches for membrane protein insertion and topology determination.

    Reference

    Duart G, Graña-Montes R, Pastor-Cantizano N, Mingarro I. Experimental and computational approaches for membrane protein insertion and topology determination. Methods. 2024 Apr 9;226:102-119. doi: 10.1016/j.ymeth.2024.03.012. Epub ahead of print. PMID: 38604415.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Cetylpyridinium chloride and chlorhexidine show antiviral activity against Influenza A virus and Respiratory Syncytial virus in vitro.

    Reference

    Rius-Salvador M, García-Múrria MJ, Rusu L, Bañó-Polo M, León R, Geller R, Mingarro I, Martinez-Gil L. Cetylpyridinium chloride and chlorhexidine show antiviral activity against Influenza A virus and Respiratory Syncytial virus in vitro. PLoS One. 2024 Feb 16;19(2):e0297291. doi: 10.1371/journal.pone.0297291. PMID: 38363760; PMCID: PMC10871507.

    [DOI] [Abstract] [Full text] [Full text PDF]

2023
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    Identification of small molecules capable of enhancing viral membrane fusion.

    Reference

    García-Murria MJ, Gadea-Salom L, Moreno S, Rius-Salvador M, Zaragoza O, Brun A, Mingarro I, Martínez-Gil L. Identification of small molecules capable of enhancing viral membrane fusion. Virol J. 2023 May 24;20(1):99. doi: 10.1186/s12985-023-02068-1. PMID: 37226231; PMCID: PMC10206591.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Computational design of BclxL inhibitors that target transmembrane domain interactions.

    SEBBM article of the month

    Reference

    Duart G, Elazar A, Weinstein JY, Gadea-Salom L, Ortiz-Mateu J, Fleishman SJ, Mingarro I, Martinez-Gil L. Computational design of BclxL inhibitors that target transmembrane domain interactions. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2219648120. PMID: 36881618.

    [DOI] [Abstract] [Abstract] [Index] [Full text] [Full text PDF]

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    Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction.

    Reference

    Papaccio, F., García-Mico, B., Gimeno-Valiente, F. et al. Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction. J Exp Clin Cancer Res 42, 8 (2023)

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