• MEMBDEATH: nova orientació en la lluita contra el càncer
2023
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    Identification of small molecules capable of enhancing viral membrane fusion.

    Reference

    García-Murria MJ, Gadea-Salom L, Moreno S, Rius-Salvador M, Zaragoza O, Brun A, Mingarro I, Martínez-Gil L. Identification of small molecules capable of enhancing viral membrane fusion. Virol J. 2023 May 24;20(1):99. doi: 10.1186/s12985-023-02068-1. PMID: 37226231; PMCID: PMC10206591.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Computational design of BclxL inhibitors that target transmembrane domain interactions.

    SEBBM article of the month

    Reference

    Duart G, Elazar A, Weinstein JY, Gadea-Salom L, Ortiz-Mateu J, Fleishman SJ, Mingarro I, Martinez-Gil L. Computational design of BclxL inhibitors that target transmembrane domain interactions. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2219648120. PMID: 36881618.

    [DOI] [Abstract] [Abstract] [Index] [Full text] [Full text PDF]

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    Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction.

    Reference

    Papaccio, F., García-Mico, B., Gimeno-Valiente, F. et al. Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction. J Exp Clin Cancer Res 42, 8 (2023)

    [DOI] [Full text] [Full text PDF] [Full text ePub]

2022
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    Intra-Helical Salt Bridge Contribution to Membrane Protein Insertion.

    Reference

    Duart G, Lamb J, Ortiz-Mateu J, Elofsson A, Mingarro I. Intra-Helical Salt Bridge Contribution to Membrane Protein Insertion. J Mol Biol. 2022 Jan 29;434(5):167467. doi: 10.1016/j.jmb.2022.167467. Epub ahead of print. PMID: 35093395.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles.

    Reference

    Bañó-Polo M, Martínez-Gil L, Sánchez Del Pino MM, Massoli A, Mingarro I, Léon R, Garcia-Murria MJ. Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles. J Oral Microbiol. 2022 Jan 24;14(1):2030094. doi: 10.1080/20002297.2022.2030094. PMID: 35087641; PMCID: PMC8788378.

    [DOI] [PMCID] [Abstract] [Full text] [Full text PDF] [ePub]

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    Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom.

    Reference

    Monteiro ML, Lima DB, Freire KA, Nicolaski Pedron C, Magalhães EP, Silva BP, García-Jareño AB, De Oliveira CS, Nunes JVS, Marinho MM, Menezes RRPPB, Orzaéz M, Oliveira Junior VX, Martins AMC. Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom. Eur J Med Chem. 2022 Nov 5;241:114624. doi: 10.1016/j.ejmech.2022.114624. Epub 2022 Jul 31. PMID: 35933786.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice.

    Reference

    Lérida-Viso A, Estepa-Fernández A, Morellá-Aucejo Á, Lozano-Torres B, Alfonso M, Blandez JF, Bisbal V, Sepúlveda P, García-Fernández A, Orzáez M, Martínez-Máñez R. Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice. Pharmacol Res. 2022 Sep;183:106356. doi: 10.1016/j.phrs.2022.106356. Epub 2022 Jul 14. PMID: 35843569.

    [DOI] [Abstract] [Full text] [Full text PDF]

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    Nanodevices for the Efficient Codelivery of CRISPR-Cas9 Editing Machinery and an Entrapped Cargo: A Proposal for Dual Anti-Inflammatory Therapy.

    Reference

    García-Fernández A, Vivo-Llorca G, Sancho M, García-Jareño AB, Ramírez-Jiménez L, Barber-Cano E, Murguía JR, Orzáez M, Sancenón F, Martínez-Máñez R. Nanodevices for the Efficient Codelivery of CRISPR-Cas9 Editing Machinery and an Entrapped Cargo: A Proposal for Dual Anti-Inflammatory Therapy. Pharmaceutics. 2022 Jul 19;14(7):1495. doi: 10.3390/pharmaceutics14071495. PMID: 35890389; PMCID: PMC9322049.

    [DOI] [Full text] [Full text PDF] [Full text ePub]

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    Split-luciferase complementary assay of NLRP3 PYD-PYD interaction indicates inflammasome formation during inflammation.

    Reference

    Isazadeh M, Amandadi M, Haghdoust F, Lotfollazadeh S, Orzáez M, Hosseinkhani S. Split-luciferase complementary assay of NLRP3 PYD-PYD interaction indicates inflammasome formation during inflammation. Anal Biochem. 2022 Feb 1;638:114510. doi: 10.1016/j.ab.2021.114510.

    [DOI] [Full text] [Full text PDF]

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    Horseradish Peroxidase-Functionalized Gold Nanoconjugates for Breast Cancer Treatment Based on Enzyme Prodrug Therapy.

    Reference

    Vivo-Llorca G, Morellá-Aucejo Á, García-Fernández A, Díez P, Llopis-Lorente A, Orzáez M, Martínez-Máñez R. Horseradish Peroxidase-Functionalized Gold Nanoconjugates for Breast Cancer Treatment Based on Enzyme Prodrug Therapy. Int J Nanomedicine. 2022 Jan 26;17:409-422. doi: 10.2147/IJN.S323802. PMID: 35115775; PMCID: PMC8802903.

    [DOI] [Full text] [Full text PDF]

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    Identification of NLRP3PYD Homo-Oligomerization Inhibitors with Anti-Inflammatory Activity.

    Reference

    Moasses Ghafary S, Soriano-Teruel PM, Lotfollahzadeh S, Sancho M, Serrano-Candelas E, Karami F, Barigye SJ, Fernández-Pérez I, Gozalbes R, Nikkhah M, Orzáez M, Hosseinkhani S. Identification of NLRP3PYD Homo-Oligomerization Inhibitors with Anti-Inflammatory Activity. Int J Mol Sci. 2022 Jan 31;23(3):1651. doi: 10.3390/ijms23031651. PMID: 35163573; PMCID: PMC8835912.

    [DOI] [Full text] [Full text PDF] [Full text ePub]

2021
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    Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases.

    Reference

    Soriano-Teruel PM, García-Laínez G, Marco-Salvador M, Pardo J, Arias M, DeFord C, Merfort I, Vicent MJ, Pelegrín P, Sancho M, Orzáez M. Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases. Cell Death Dis. 2021 Dec 13;12(12):1155. doi: 10.1038/s41419-021-04420-1. PMID: 34903717; PMCID: PMC8667020.

    [ DOI] [ PMCID] [ Abstract] [ Full text] [ Full text PDF] [ Full text ePub]

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    Folding and Insertion of Transmembrane Helices at the ER.

    Reference

    Whitley P, Grau B, Gumbart JC, Martínez-Gil L, Mingarro I. Folding and Insertion of Transmembrane Helices at the ER. Int J Mol Sci. 2021 Nov 26;22(23):12778. doi: 10.3390/ijms222312778. PMID: 34884581.

    [ DOI] [ Abstract] [ Abstract] [ Full text] [ Full text PDF]

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    Controllable membrane remodeling by a modified fragment of the apoptotic protein Bax.

    Reference

    Schaefer KG, Grau B, Moore N, Mingarro I, King GM, Barrera FN. Controllable membrane remodeling by a modified fragment of the apoptotic protein Bax. Faraday Discuss. 2021 Sep 22. doi: 10.1039/d0fd00070a. Epub ahead of print. PMID: 34549736.

    [ DOI] [ Abstract] [ Full text] [ Full text PDF]

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    Methodological approaches for the analysis of transmembrane domain interactions: A systematic review.

    Reference

    Gerard Duart, Brayan Grau, Ismael Mingarro, Luis Martinez-Gil. Methodological approaches for the analysis of transmembrane domain interactions: A systematic review. Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1863, Issue 12, 2021, 183712, ISSN 0005-2736.

    [ DOI] [ Full text] [ Full text PDF]

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    Targeted-lung delivery of dexamethasone using gated mesoporous silica nanoparticles. A new therapeutic approach for acute lung injury treatment.

    Reference

    García-Fernández A, Sancho M, Bisbal V, Amorós P, Marcos MD, Orzáez M, Sancenón F, Martínez-Máñez R. Targeted-lung delivery of dexamethasone using gated mesoporous silica nanoparticles. A new therapeutic approach for acute lung injury treatment. J Control Release. 2021 Sep 10;337:14-26. doi: 10.1016/j.jconrel.2021.07.010. Epub 2021 Jul 13. PMID: 34265332.

    [ DOI] [ Abstract] [ Full text] [ Full text PDF]

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    Understanding MCL1: from cellular function and regulation to pharmacological inhibition.

    Reference

    Sancho, M., Leiva, D., Lucendo, E. and Orzáez, M. Understanding MCL1: from cellular function and regulation to pharmacological inhibition. FEBS J. 2021 Jul 26. doi: 10.1111/febs.16136. Epub ahead of print. PMID: 34310025.

    [ DOI] [ Full text] [ Full text PDF]

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    Conformational clamping by a membrane ligand activates the EphA2 receptor.

    Reference

    Westerfield JM, Sahoo AR, Alves DS, Grau B, Cameron A, Maxwell M, Schuster JA, C T Souza P, Mingarro I, Buck M, Barrera FN. Conformational clamping by a membrane ligand activates the EphA2 receptor. J Mol Biol. 2021 Jul 3:167144. doi: 10.1016/j.jmb.2021.167144. Epub ahead of print. PMID: 34229012.

    [ DOI] [ Abstract] [ Full text] [ Full text PDF] [ Full text PDF]

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    The past, present, and future of breast cancer models for nanomedicine development.

    Reference

    Boix-Montesinos P, Soriano-Teruel PM, Armiñán A, Orzáez M, Vicent MJ. The past, present, and future of breast cancer models for nanomedicine development. Adv Drug Deliv Rev. 2021 Jun;173:306-330. doi: 10.1016/j.addr.2021.03.018. Epub 2021 Mar 31. PMID: 33798642; PMCID: PMC8191594.

    [ DOI] [ PMCID] [ Abstract] [ Full text] [ Full text PDF]

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    Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells.

    Reference

    Candela-Noguera V, Vivo-Llorca G, Díaz de Greñu B, Alfonso M, Aznar E, Orzáez M, Marcos MD, Sancenón F, Martínez-Máñez R. Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells. Nanomaterials (Basel). 2021 May 14;11(5):1298. doi: 10.3390/nano11051298. PMID: 34069171; PMCID: PMC8156333.

    [ DOI] [ PMCID] [ Abstract] [ Abstract] [ Full text] [ Full text PDF]

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    The importance of transmembrane domain interactions in the viral control of apoptosis.

    Reference

    Duart G, Mingarro I, Martinez-Gil L. The importance of transmembrane domain interactions in the viral control of apoptosis. Mol Cell Oncol. 2021 May 3;8(3):1911290. doi: 10.1080/23723556.2021.1911290. PMID: 34027047; PMCID: PMC8128167.

    [ DOI] [ Abstract] [ Full text] [ Full text PDF] [ Full text PDF]

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    The SARS-CoV-2 envelope (E) protein has evolved towards membrane topology robustness.

    Reference

    Duart G, García-Murria MJ, Mingarro I. The SARS-CoV-2 envelope (E) protein has evolved towards membrane topology robustness. Biochim Biophys Acta Biomembr. 2021 Mar 23:183608. doi: 10.1016/j.bbamem.2021.183608. Epub ahead of print. PMID: 33771486.

    [ DOI] [ Abstract] [ Full text] [ Full text PDF] [ Full text PDF]

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    BOK-MCL1 transmembrane interactions: a challenging target for cancer therapy.

    Reference

    Sancho M, Orzáez M. BOK-MCL1 transmembrane interactions: a challenging target for cancer therapy. Mol Cell Oncol. 2021 Jan 11;8(1):1859918. doi: 10.1080/23723556.2020.1859918. PMID: 33553610; PMCID: PMC7849717.

    [ DOI] [ Abstract] [ Full text] [ Full text] [ Full text PDF] [ Full text PDF]

2020
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    MUC1 Aptamer-Capped Mesoporous Silica Nanoparticles for Navitoclax Resistance Overcoming in Triple-Negative Breast Cancer.

    Reference

    Vivo-Llorca G, Candela-Noguera V, Alfonso M, García-Fernández A, Orzáez M,Sancenón F, Martínez-Máñez R. MUC1 Aptamer-Capped Mesoporous Silica Nanoparticles for Navitoclax Resistance Overcoming in Triple-Negative Breast Cancer. Chemistry. 2020 Dec 9;26(69):16318-16327. doi: 10.1002/chem.202001579. Epub 2020 Oct 29. PMID: 32735063.

    [ DOI] [ Full text] [ Full text PDF] [ Full text PDF]

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    Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis.

    SEBBM article of the month

    Reference

    García-Murria MJ, Duart G, Grau B, Diaz-Beneitez E, Rodríguez D, Mingarro I, Martínez-Gil L. Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis. Nat Commun. 2020 Nov 27;11(1):6056. doi: 10.1038/s41467-020-19881-9. PMID: 33247105; PMCID: PMC7695858.

    [ DOI] [ Abstract] [ Full text] [ Full text PDF] [ Full text PDF]

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    Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis.

    Reference

    Lucendo E, Sancho M, Lolicato F, Javanainen M, Kulig W, Leiva D, Duart G, Andreu-Fernández V, Mingarro I, Orzáez M. Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis. Proc Natl Acad Sci U S A. 2020 Oct 22:202008885.

    [ DOI] [ Abstract] [ Full text] [ Full text PDF] [ Full text PDF]

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    SARS-CoV-2 envelope protein topology in eukaryotic membranes.

    Reference

    Gerard Duart, Mª Jesús García-Murria, Brayan Grau, José M. Acosta-Cáceres, Luis Martínez-Gil and Ismael Mingarro SARS-CoV-2 envelope protein topology in eukaryotic membranes. Open Biology, 10. The Royal Society. [9-9-2020]

    [ DOI] [ Full text] [ Full text PDF]

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    Real-Time In Vivo Detection of Cellular Senescence through the Controlled Release of the NIR Fluorescent Dye Nile Blue.

    Reference

    Lozano-Torres B, Blandez JF, Galiana I, García-Fernández A, Alfonso M, Marcos MD, Orzáez M, Sancenón F, Martínez-Máñez R. Real-Time In Vivo Detection of Cellular Senescence through the Controlled Release of the NIR Fluorescent Dye Nile Blue. Angew Chem Int Ed Engl. 2020 Aug 24;59(35):15152-15156. doi: 10.1002/anie.202004142. Epub 2020 Jun 8. PMID: 32416002.

    [ DOI] [ Full text] [ Full text PDF] [ Full text PDF]

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    Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic.

    Reference

    Galiana I, Lozano-Torres B, Sancho M, Alfonso M, Bernardos A, Bisbal V, Serrano M, Martínez-Máñez R, Orzáez M. Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic. J Control Release. 2020 Jul 10;323:624-634. doi: 10.1016/j.jconrel.2020.04.045. Epub 2020 May 4. PMID: 32376460.

    [ DOI] [ Full text] [ Full text PDF] [ Full text PDF]

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    Insertion of Bacteriorhodopsin Helix C Variants into Biological Membranes.

    Reference

    Manuel Bañó-Polo, Luis Martínez-Gil, Francisco N. Barrera, Ismael Mingarro Insertion of Bacteriorhodopsin Helix C Variants into Biological Membranes. ACS Omega 2020, 5, 556−560.

    [ Abstract] [ Full text PDF]